Aprea Therapeutics Inc

NASDAQ:APREUnited States

Aprea Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on precision oncology through synthetic lethality. The Company's advanced synthetic lethality product candidate is ATRN-119, a clinical-stage small molecule inhibitor of ataxia telangiectasia and Rad3-related (ATR) a kinase that plays a critical role in DNA damage response (DDR). ATR and Checkpoint Kinase 1 are critical DDR kinases that prevent the collapse of replication forks into DNA double-strand breaks. It has completed all IND enabling studies for its oral, small molecule WEE1 inhibitor, APR-1051, and received United States Food and Drug Administration (FDA) clearance of its IND. It has an early-stage program that is in the lead optimization stage, for an undisclosed DDR target. The Company is evaluating potential combination opportunities within its pipeline, including research on the combination of ATRN-119 and APR-1051 that is supported by a Phase II SBIR grant from the National Cancer Institute.

Contact Information

Headquarters

3805 OLD EASTON ROADDOYLESTOWN, PA, United States 18902

Phone

617-463-9385

Fax

302-655-5049

Executives

Independent Chairman of the Board

Richard Peters

President, Director

Oren Gilad

Chief Financial Officer, Senior Vice President, Secretary

John Hamill

Lead Independent Director

John Henneman

Director

Jean-Pierre Bizzari