Olema Pharmaceuticals Inc

NASDAQ:OLMAUnited States

Olema Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on the discovery, development, and commercialization of targeted therapies for women's cancers. Its lead product candidate, OP-1250, is an oral therapy with combined activity as both a complete estrogen receptor (ER) antagonist (CERAN) and a selective ER degrader (SERD). The Company's OP-1250 is an oral small molecule clinical-stage product candidate for the treatment of endocrine-driven cancers. OP-1250, both as a monotherapy and in combination with inhibitors of cyclin-dependent kinase four and six (CDK4/6) demonstrated robust tumor shrinkage in several xenograft models, including ESR1 and PIK3CA mutations and central nervous system (CNS), metastasis. It is in the Phase I/ II clinical trial, and in Phase Ib/ II combination with palbociclib, in patients with metastatic ER-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer.

Contact Information

Headquarters

780 Brannan StreetSAN FRANCISCO, CA, United States 94103

Phone

415-651-3316

Fax

302-674-5266

Executives

Director

Ian Clark

President, Chief Executive Officer, Director

Sean Bohen

Chief Operating and Financial Officer

Shane Kovacs

Chief Discovery and Non-Clinical Development Officer

David Myles

Chief Medical Officer

Naseem Zojwalla