Palisade Bio Inc

NASDAQ:PALIUnited States

Palisade Bio, Inc. is a biopharmaceutical company focused on developing novel therapeutics for serious chronic gastrointestinal diseases. It is engaged in advancing a PALI-2108 for the treatment of IBD, including UC and CD and are researching PALI-1908. IBD is a chronic condition characterized by inflammation within the gastrointestinal tract. UC primarily affects the colon and the rectum. CD can affect any part of the gastrointestinal tract, from the mouth to the anus. PALI-2108 is a prodrug PDE4 inhibitor that operates through a mechanism within colon tissues, targeting the key enzyme phosphodiesterase-4 (PDE4). This enzyme is pivotal in cAMP hydrolysis, and by inhibiting PDE4, intracellular cAMP levels are elevated. This elevation leads to the downregulation of inflammatory cytokines and a reduction in the expression of cell adhesion molecules. By modulating these processes, PALI-2108 prevents the local infiltration and activation of inflammatory cells in the colon tissues.

Contact Information

Headquarters

7750 El Camino Real, Suite 5200CARLSBAD, CA, United States 92009

Phone

858-704-4900

Fax

302-697-4597

Executives

Independent Chairman of the Board

Donald Williams

Interim Chief Executive Officer, Chief Financial Officer, Director

J. D. Finley

Chief Operating Officer

Robert Mcrae

Chief Medical Officer

Mitchell Jones

Independent Director

Margery Fischbein