Actuate Therapeutics Inc

NASDAQ:ACTUUnited States

Actuate Therapeutics, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on developing therapies for the treatment of high impact, difficult to treat cancers through the inhibition of glycogen synthase kinase-3 (GSK-3). The Company is developing elraglusib, a small molecule that is designed to enter cancer cells and block the function of the enzyme GSK-3b, a master regulator of complex biological signaling cascades, including those mediated by oncogenes, that lead to tumor cell survival, growth, migration, and invasion. Its lead program, Elraglusib Injection, is an intravenous solution of elraglusib for the treatment of metastatic pancreatic ductal adenocarcinoma (mPDAC). Elraglusib Injection has been evaluated in a Phase I dose escalation study (Actuate-1801 Part 1) in 238 adult patients. Elraglusib is designed to act as a mediator of anti-tumor immunity through the inhibition of NF-kB and regulates multiple immune checkpoints and immune cell function.

Contact Information

Headquarters

1751 RIVER RUN, SUITE 400FORT WORTH, TX, United States 76107

Phone

847-986-4190

Fax

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Executives

Chairman of the Board

Aaron Fletcher

President, Chief Executive Officer, Director

Daniel Schmitt

Chief Financial Officer

Paul Lytle

Chief Operating Officer

Andrew Mazar

Independent Director Nominee

Jason Keyes